Prolongation of Life cordycepin from Cordyceps militaris from Oule Biotech team .

2024-05-22 07:20:44 Company news 270

Xi 'an Oule Biotechnology Co., LTD., since 2018, jointly developed and planted Cordyceps militaris (Northern Cordyceps) with Northeast Scientific Research Institute, covering an area of 500 acres, every grass is carefully cultivated by our professional researchers. The content of cordycepin in our artificially cultivated cordycepin exceeded 4% and reached 4.7%.To provide domestic and foreign customers with the best quality Cordyceps militaris.

We have customized cordyceps tablets for customers, which are loved by the vast market.If you are interested in Cordyceps militaris ,welcome contact us .

Cordyceps militaris

Cordyceps militaris (scientific name: Cordyceps militaris (L.ex Fr.) Link.) is a fungus of the genus Cordyceps in the family Clavicepsaceae, also known as Cordyceps militaris, Cordyceps militaris, referred to as Cordyceps militaris. Cordyceps militaris is a complex composed of two parts: the stroma (that is, the grass part) and the sclerotium (that is, the corpse part of the insect). A single or several spores grow out from the host's head, sometimes from the insect's body segments, orange-yellow, usually unbranched, sometimes branched, 3 to 5 cm high, with a rod-shaped head, 1 to 2 cm long. It is 3~5 mm thick and has a rough surface. The ascus shell is exposed, nearly conical, and the lower part is buried in the outer layer of the head, 400~500 microns × 4~5 microns, containing 8 strip-shaped spores. The spores are slender, almost full of ascus, about 1 micron in diameter, develop transverse septa when mature, and break into small segments 2 to 3 microns long. The handle of the base is nearly cylindrical, 2.5 to 4 cm long, and solid inside.

Cordyceps militaris parasitizes on the cocoons and pupae of lepidopteran larvae; it often appears in the forest litter. Wild Cordyceps militaris is distributed throughout the world. In China, it is mainly distributed in Yunnan, Anhui, Fujian, Gansu, Guangdong, Guangxi, Guizhou, Hebei, Heilongjiang, Hubei, Jilin, Liaoning, Inner Mongolia, Shandong, Shaanxi, Sichuan, Taiwan, Tibet, Zhejiang and other places.

Cordyceps militaris is a dual-purpose fungus, its protein content is as high as 40.7%, which contains not only a complete variety of essential amino acids, sufficient quantity, and appropriate proportion. Artificial cultivation of Cordyceps militaris also rich in vitamins and minerals, has a good edible value. Cordyceps pupae can be used as medicine, with flat taste sweet, benefit lung kidney, hemostasis and phlegm, generally can be used for tuberculosis, the elderly weak, anemia weak and other diseases. Cordycepin is rich in cordycepic acid, cordycepin, ergosterol, etc., which has the effect of expanding trachea, sedating, resisting all kinds of bacteria and lowering blood pressure.

Morphological characteristics

Fruiting body: annual, single or several growing from the head of the host, cladlike, clearly divided into two parts of the head and stalk, 15~30 mm high, 2~3 mm in diameter; Head fertile, irregularly clavicular or conical, orange-red when fresh, fleshy, rough or spotted, reddish-brown after drying, brittle, 7-19 mm high, 2-3 mm in diameter; Stalk sterile, cylindrical, light orange-red when fresh, light reddish-brown when dry, smooth, with no distinct boundary with the head, stalk base connected with the insect pupa.

Mycelium: The mycelium diaphragm is simply separated, the mycelium is colorless, frequently separated, thin-walled, and the diameter of the mycelium varies greatly. The shape of the mycelium ranges from filamentous to polygonal, smooth without crystallization, and the diameter of the filamentous mycelium is 3~3.8 microns. The stalk hypha is colorless, thin-walled, without constriction at the separator, parallel, with a diameter of 2.5 to 4.5 microns.

Hymenium: mainly composed of ascus and lateral filaments; Ascus filamentous, colorless, thin-walled, 400~500 μm ×4~5 μm, diameter 3~4 μm, 8 endospores; Lateral filaments are rare.

Spores: ascus spores arranged in chains in the ascus, cylindrical to fusiform, colorless, thin-walled, smooth, size 2~5× (0.8~) 0.9 μm ~1.2 (~1.4) μm, average length L=3.45 μm, average width W=1 μm, aspect ratio Q=2.99~3.95 (n=65/2).

Habit of growth

Cordyceps pupae is mainly parasitic on the cocoon and pupa of lepidoptera larvae, but also parasitic on the adult insects or larvae. Cordyceps fungi can infect host insects in a variety of ways, and these fungi can enter the body through the body wall, stomata, mouthparts or directly through other pores in the body to increase the chance of infection. The infection process of cordyceps fungus can be divided into three basic processes, namely invasion, parasitism (fungal development before the death of the insect) and saprophytism (fungal growth after the death of the host).

When sensitive insects swallow food containing ascospores, cordyceps bacteria enter the body through the digestive tract and cause infection. In addition, cordyceps invasion through the insect body surface is also a major way. The upper epidermis of insects is composed of chitin layer, and Cordyceps can secrete a hydrolase to decompose chitin, destroying the integrity of the upper epidermis, which is conducive to the invasion of Cordyceps bacteria.

After the cordyceps bacteria invade the insect body, the internal organs are used for nutrition, the mycelium spreads, and then fills the whole insect body. When the insect is still alive, the insect stops feeding due to toxic reaction, and there is paralysis and slow action. When the mycelium infects the larvae for several days, the outer shell of the worm body will appear obvious discoloration, that is, from dark brown to light yellow, and then the whole body will be covered with grayish white mycelium, and finally the worm body will die. In poor conditions, the mycelium will form a hard mycelium mass, and its peripheral tissue forms a stronger skin shell called the sclerotium. After the environmental conditions improve, the mycelium in the insect body will Pierce the outer surface from the porous part and the soft part of the insect body to form a variety of fruit bodies, forming a complete cordyceps.

Edibleness

Cordyceps militaris is rich in nutritional value. Its protein content is as high as 40.7%, 15.25% higher than that of Cordyceps sinensis (25.4%). Its protein contains 19 kinds of amino acids, among which the amino acids essential to human body are not only complete in variety, sufficient in quantity, but also in appropriate proportion, basically consistent with Cordyceps sinensis. Artificial cultivation of Cordyceps militaris also rich in vitamins and minerals, has a good edible value.

Medicinal value

Cordyceps pupa is sweet, beneficial to lung and kidney, hemostasis and phlegm, generally can be used for tuberculosis, the elderly weak, anemia weak and other diseases. Zhao Xuemin pointed out in "Compendium of Materia Medica" that Cordyceps pupa "can cure 100 deficiency and 100 damage."

The clinical and medical effect of cordyceps militaris is no less than that of Cordyceps militaris. Cordyceps militaris contains rich cordycepic acid, cordycepin, ergosterol, etc., which has the effect of expanding trachea, sedating, resisting various kinds of bacteria and lowering blood pressure. Cordycepin has obvious antagonistic or inhibitory effects on Bacillus subtilis, mouse Eichsoni's ascites wart, human nasopharyngeal carcinoma KB cells and human epidermoid wart Kela cells. Cordycepic acid can treat cerebral thrombosis, cerebral embolism, vasospasm, cerebral hemorrhage and other diseases, but also can promote metabolism, diuresis and so on. Cordyceps polysaccharide can improve the detoxification ability of liver and protect liver.

Conservation status

Cordyceps pupa is listed in the "Redlist of China's Biodiversity - Macrofungi Volume", and the protection level is near threatened (NT).